abstract：:The location and level of IL-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases were studied by in situ hybridization. These diseases are associated with considerable changes in the levels of local production ...

journal_title：Bulletin of experimental biology and medicine

authors： Zhdanov AV,Kurbanova DF,Sosulina LY,Davydova MP,Ezhova LS,Sukhikh GT

更新日期：2003-03-01 00:00:00

abstract：:Here we review the mechanisms underlying systemic regulation of the genome in brain nerve cells. Expression of early and late behavioral genes is regulated by systemic processes in dominant functional systems. The main elements of this molecular and genetic cascade are similar during learning and development. ...

journal_title：Bulletin of experimental biology and medicine

authors： Anokhin KV,Sudakov KV

更新日期：2003-02-01 00:00:00

abstract：:Solid-phase ELISA revealed increased content of macrophage-granulocyte colony-stimulating factor and basic fibroblast growth factor in the serum of hyperlipoproteinemic patients. ...

journal_title：Bulletin of experimental biology and medicine

authors： Saburova OS,Tvorogova MG,Soboleva EL

更新日期：2003-02-01 00:00:00

abstract：:Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular an...

journal_title：Bulletin of experimental biology and medicine

authors： Lushnikova EL,Nepomnyashchikh LM

更新日期：2003-02-01 00:00:00

abstract：:We studied the effects of potentiated antibodies to morphine and mu-opioid receptors on animal behavior in the forced swimming test and reaction of light avoidance after morphine withdrawal. Antibodies to morphine normalized behavioral characteristics in the forced swimming test, while antibodies to mu-opioid receptor...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI,Shtark MB

更新日期：2003-01-01 00:00:00

abstract：:Antibodies to cyclophosphamide obtained by homeopathic potentiation and administered in ultralow doses exhibit no antiblastic activity and did not modulate the effectiveness of cyclophosphamide during antitumor therapy of animals with transplanted tumors (Lewis lung carcinoma and Ehrlich adenocarcinoma). ...

journal_title：Bulletin of experimental biology and medicine

authors： Amosova EN,Zueva EP,Razina TG,Krylova SG,Shilova NV,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:Ultralow doses of antibodies to histamine in produced an antiproliferative effect on experimental animals with inflammation. Analgesic activity of antibodies to histamine was revealed on the model of acetic acid-induced writhing. ...

journal_title：Bulletin of experimental biology and medicine

authors： Krylova SG,Razina TG,Zueva EP,Amosova EN,Shilova NV,Dugina YL,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:We studied the effects of individual or combination treatment with monoclonal antibodies 5F5-B6 in ultralow doses specifically marking mossy fibers in rat hippocampus and antibodies to S100 protein during long-term post-tetanic potentiation in hippocampal slices. The possible mechanisms of changes produced by therapeu...

journal_title：Bulletin of experimental biology and medicine

authors： Epstein OI,Beregovoi NA,Pankova TM,Sorokina NS,Starostina MV,Shtark MB

更新日期：2003-01-01 00:00:00

abstract：:The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:An open comparative clinical study evaluated the efficiency of Proproten-100 in reliving affective, somatovegetative, behavioral, and cognitive post-withdrawal disorders and manifestations of primary pathological alcohol addiction in patients with alcohol dependence in the stage of therapeutic remission. We compared t...

journal_title：Bulletin of experimental biology and medicine

authors： Bokhan NA,Abolonin AF,Krylov EN,Vetlugina TP,Ivanova SA,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:Acute experiments on cats showed that dynorphin A(1-13) modulates pulse activity of afferent neurons and interneurons in the bulbar cardiovascular center against the background of stable blood pressure. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhailova SD,Vasil'eva TV,Semushkina TM,Storozhakov GI

更新日期：2003-01-01 00:00:00

abstract：:We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Remmel' NN,Kratasyuk VA,Maznyak OM,Inzhevatkin EV,Nefedov VP

更新日期：2003-01-01 00:00:00

abstract：:No appreciable disorders of cellular immunity were detected in patients with glandular cystic endometrial hyperplasia. Atypical endometrial hyperplasia was associated with quantitative changes in T lymphocytes and their subpopulations, decreased level of lymphocytes carrying activation antigens, and increased count of...

journal_title：Bulletin of experimental biology and medicine

authors： Lysenko ON,Strizhova NV,Kholodova ZhL

更新日期：2003-01-01 00:00:00

abstract：:We studied the effect of leukemia-inhibiting factor on bilayer lipid membranes. Leukemia-inhibiting factor in a concentration of 10 ng/ml nonspecifically increased membrane permeability for ions. Leukemia-inhibiting factor acts as a surface-active substance on bilayer lipid membranes. ...

journal_title：Bulletin of experimental biology and medicine

authors： Serysheva VV,Borisova MP,Mezhevikina LM,Poltavtseva RA,Sukhkih GT

更新日期：2002-12-01 00:00:00

abstract：:Circadian dynamics of rectal reactivity was studied in humans with regular and irregular rhythms of bowel evacuation function by chronoenterography. In individuals with regular rhythm of this function (stool 7 days per week) the acrophase of circadian rhythm of rectal reactivity was observed in morning hours, while in...

journal_title：Bulletin of experimental biology and medicine

authors： Shemerovskii KA

更新日期：2002-12-01 00:00:00

abstract：:The type and magnitude of changes in blood flow in the anterior (cranial) and posterior (caudal) caval veins and shifts in the mean right atrial pressure induced by catecholamines (epinephrine and norepinephrine) were studied in acute experiments on cats. It was found that irrespective of right atrial pressure shifts,...

journal_title：Bulletin of experimental biology and medicine

authors： Tkachenko BI,Evlakhov VI,Poyasov IZ

更新日期：2002-11-01 00:00:00

abstract：:The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% ...

journal_title：Bulletin of experimental biology and medicine

authors： Churilova IV,Zinov'ev EV,Paramonov BA,Drozdova YI,Sidel'nikov VO,Chebotarev VY

更新日期：2002-11-01 00:00:00

abstract：:In biopsy specimens of the gastric and duodenal mucosa from patients with psoriasis we revealed severe degenerative and dystrophic changes in cells of the surface and glandular epithelium with destruction of functionally important cytoplasmic organelles. The stroma of the gastric mucosa was characterized by hyperplasi...

journal_title：Bulletin of experimental biology and medicine

authors： Khardikova SA,Nepomnyashchikh GI,Aidagulova SV,Lapii GA

更新日期：2002-11-01 00:00:00

abstract：:In August rats more resistant to acute stress-induced gastric damage than Wistar rats, preadaptation to nondamaging stress exposure did not prevent damage and even potentiated these damages. By contrast, in Wistar rats such adaptation decreased gastric damage caused by acute stress. Higher initial resistance of August...

journal_title：Bulletin of experimental biology and medicine

authors： Pshennikova MG,Popkova EV,Shimkovich MV

更新日期：2002-10-01 00:00:00

abstract：:We studied sterility and toxicity of vaccine LS1 containing aberrant gangliosides isolated from brain bioptates of 48 patients with gliomas of different malignancy and covalently bound to keyhole limpet hemocyanin. The vaccine was safe. This preparation produced no side effects in experimental animals. Our findings su...

journal_title：Bulletin of experimental biology and medicine

authors： Lombardi V,Shnaar R,Minev B,Misasi R,Gitstsi Kh,Sorice M,Troncone A

更新日期：2002-10-01 00:00:00

abstract：:Clinical and laboratory studies were carried out in 38 pregnant women with antiphospholipid syndrome. Increased functional activity of platelets and decreased protein-producing function of the placenta were observed starting from the early terms of gestation. These disorders were followed by the development of hyperco...

journal_title：Bulletin of experimental biology and medicine

authors： Bogdanovich RN,Chikalovets IV

更新日期：2002-10-01 00:00:00

abstract：:We studied properties of cloned BACE mRNA (beta-site of the enzyme cleaving amyloid precursor protein) and evaluated the possibility of using this clone for identification and/or prediction of neurodegenerative disorders associated with cholinergic deficiency. Wistar rats subjected to immunohistochemical destruction o...

journal_title：Bulletin of experimental biology and medicine

authors： Lushchekina EA,Bigl M,Apelt J,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2002-09-01 00:00:00

abstract：:Inductors of the monooxygenase system benzonal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by a-naphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metaboli...

journal_title：Bulletin of experimental biology and medicine

authors： Saratikov AS,Novozheeva TP,Akhmedzhanov RR

更新日期：2002-09-01 00:00:00

abstract：:Brain pathology (acute hypoxia and posthypoxic encephalopathy) is associated with less pronounced hyperplasia of the bone marrow erythroid stem (due to decreased count of proliferating committed precursors) and hemolytic anemia, while secretory activity of stromal cells of the hemopoiesis-inducing microenvironment is ...

journal_title：Bulletin of experimental biology and medicine

authors： Gol'dberg ED,Dygai AM,Zyuz'kov GN,Gur'yantseva LA,Suslov NI

更新日期：2002-08-01 00:00:00

abstract：:Mutant alleles CYP2D63 and CYP2D64 were detected by PCR in 33 individuals. All examinees were given 50 mg methoprolol (orally). Plasma concentrations of the drug and its major metabolite was determined by high performance liquid chromatography and arterial pressure and heart rate were monitored. The rate of methoprolo...

journal_title：Bulletin of experimental biology and medicine

authors： Ramenskaya GV,Savchenko AY,Agafonov AA,Sychev DA,Andreev DA,Kukes VG

更新日期：2002-08-01 00:00:00

abstract：:Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predomina...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh GI,Levitskii VA,Dolgovykh AK,Naumova LA

更新日期：2002-08-01 00:00:00

abstract：:Plasma concentration of immune complexes and antibodies to serotonin and dopamine were higher in patients with Alzheimer's disease compared to mentally healthy volunteers of the same age. Plasma concentrations of antibodies to serotonin and dopamine decreased with the increase in the duration of this disease. ...

journal_title：Bulletin of experimental biology and medicine

authors： Davydova TV,Mikovskaya OI,Fomina VG,Voskresenskaya NI,Doronina OA

更新日期：2002-07-01 00:00:00

abstract：:In patients with viral and bacterial infectious mononucleosis during the acute period of disease and clinical convalescence blood content of CD72(+)and CD16(+)lymphocytes increased compared to normal. The count of CD8(+)cells increased in viral mononucleosis during convalescence and these changes persist in delayed pe...

journal_title：Bulletin of experimental biology and medicine

authors： Novitskii VV,Urazova OI,Naslednikova IO,Pomogaeva AP,Syusina LV

更新日期：2002-07-01 00:00:00

abstract：:We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...

journal_title：Bulletin of experimental biology and medicine

authors： Denisov-Nikol'skii YI,Shafranov VV,Borkhunova EN,Doktorov AA,Mikhaleva LM,Mikhalev AP

更新日期：2002-07-01 00:00:00

abstract：:We studied changes in protein composition and their effects on convulsive activity in drug-induced and electrical kindling. Injection of protein fraction of brain extract from animals subjected to metronidazole-induced kindling to intact recipients reduced their sensitivity to the convulsant (i. e. increased the dose ...

journal_title：Bulletin of experimental biology and medicine

authors： Karpova MN,Karganov MY,Klishina NY,Khlebnikova NN,Kryzhanovskii GN

更新日期：2002-06-01 00:00:00

abstract：:Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented redu...

journal_title：Bulletin of experimental biology and medicine

authors： Zhuikova SE,Sergeev VI,Samonina GE,Myasoedov NF

更新日期：2002-06-01 00:00:00

abstract：:We measured the content of glutathione and activity of glutathione-metabolizing and antioxidant enzymes superoxide dismutase and catalase in samples obtained from 52 patients with malignant lung tumors and 20 patients with benign lung tumors. The content of glutathione and activity of glutathione-metabolizing enzymes ...

journal_title：Bulletin of experimental biology and medicine

authors： Korotkina RN,Matskevich GN,Devlikanova ASh,Vishnevskii AA,Kunitsyn AG,Karelin AA

更新日期：2002-06-01 00:00:00

abstract：:Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment a...

journal_title：Bulletin of experimental biology and medicine

authors： Zefirov TL,Ziyatdinova NI,Gainullin AA,Zefirov AL

更新日期：2002-05-01 00:00:00

abstract：:The effects of Biopin (ointment containing pine resin) used in the treatment of burns, wounds, and pyoinflammatory processes on cell composition of the wound surface (smears) and granulation tissue were studied on rats. In vitro antibacterial activity of the drug was also evaluated. At the early stage of inflammation ...

journal_title：Bulletin of experimental biology and medicine

authors： Simbirtsev AS,Konusova VG,Mchelidze GSh,Fidarov EZ,Paramonov BA,Chebotarev VY

更新日期：2002-05-01 00:00:00

abstract：:A total of 107 patients with primary gout were examined. The pituitary-gonadal system is imbalanced in male patients with gout, which manifests by hyperproduction of progesterone and suppressed production of testosterone and estradiol. These changes are more pronounced in patients with chronic arthritis and proteinuri...

journal_title：Bulletin of experimental biology and medicine

authors： Mukhin IV,Ignatenko GA,Nikolenko VY

更新日期：2002-05-01 00:00:00

abstract：:The content of phospholipids in various tissues was studied during synergistic interaction between two branches of the autonomic nervous system. We found higher myocardial content of choline-containing phospholipids and lower rigidity of erythrocyte membranes in rabbits with pronounced sympathetic potentiation of the ...

journal_title：Bulletin of experimental biology and medicine

authors： Lychkova AE,Smirnov VM

更新日期：2002-04-01 00:00:00

abstract：:The interaction between recombinant soluble CD4 receptor (rsCD4) with human apolipoprotein A-I was studied by enzyme-linked immunosorbent assay. Our findings suggest that HIV-1 and human apolipoprotein A-I compete for the CD4 receptor and receptor for apoA-I. ...

journal_title：Bulletin of experimental biology and medicine

authors： Panin LE,Kostina NE

更新日期：2002-04-01 00:00:00

abstract：:The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

journal_title：Bulletin of experimental biology and medicine

authors： Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

更新日期：2002-04-01 00:00:00

abstract：:Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...

journal_title：Bulletin of experimental biology and medicine

authors： Dreval' AA,Perminova GI,Kuznetsov NA,Sokolov AA,Laberko LA,Ryzhkova LV

更新日期：2002-04-01 00:00:00

abstract：:Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The ...

journal_title：Bulletin of experimental biology and medicine

authors： Afanas'ev SA,Lukavskaya IA,Kandinskii ML,Medvedev MA

更新日期：2002-03-01 00:00:00